Co-opted integrin signaling in ErbB2-induced mammary tumor progression
نویسندگان
چکیده
منابع مشابه
β4 Integrin Amplifies ErbB2 Signaling to Promote Mammary Tumorigenesis
Amplification of the ErbB2 locus, which encodes a receptor tyrosine kinase, is common in aggressive breast tumors and correlates with poor prognosis. The mechanisms underlying ErbB2-mediated breast carcinoma progression remain incompletely defined. To examine the role of the signaling and cell-adhesion receptor beta 4 integrin during ErbB2-mediated tumorigenesis, we introduced a targeted deleti...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2006
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2006.07.015